• Bleeping Lobster
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    7 months ago

    I lost a friend to ket. He was partying with bad people, he was sick, choked on his vomit and they stole his stuff / left him to die.

    Ketamine is a very interesting ride, and has wonderful potential as an antidepressant, but for the love of yourself (and my badly missed friend, John the magic man), PLEASE have someone compus mentus watching over you while you experience it, if you choose to do so.

    Also strongly recommend you DO NOT mix with alcohol.

    • @flooppoolf@lemmy.world
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      7 months ago

      Ketamine also should not be used in people with high blood pressure as it may further increase it and heart rates to dangerous levels.

      Hot tubs increase heart rate as well however the blood pressure is lowered.

      Oh yah, he had heart disease which is a no go with hot tubs.

        • KingJalopy
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          7 months ago

          Meh, I’ve been on bupe for 4 years and love hot baths and such, it’s not that big of a deal. His previous issues were more of a problem than that. Buprenorphine is somewhat of a miracle drug for those of us who have been trying to battle opiate addiction. It has very very little side effects and does nothing more than stop the craving and make someone like myself feel like a normal person instead of like the fucking junkie that I am (was).

          Not denying that it has depressive effects on respiratory and other systems. But if you’re not abusing other drugs while using it, there’s really not any problem with that.

          • @Crismus@lemmy.world
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            77 months ago

            I’m on bupe as well, but both together is a bad news with the hot water. It increases the chance to sleep, and falling asleep in a hot tub will make you drown.

            Add to his known addictive personality that he has had a problem with for decades, he shouldn’t have been on that combination.

            I personally hate bupe because it rarely works on my chronic pain I’ve had for the last 20 years. The media blew up the legal fentanyl patches I safely took almost 10 years ago that gave me a normal life. This will be just another excuse to restrict medication that works. A buddy of mine has stopped his suicidal issues because of ketamine therapy.

    • @kboy101222@lemm.ee
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      107 months ago

      They gave me ketamine the last time I was in the hospital for pain so they could knock me out.

      It was the single worst experience of my life, even worse than the injury I was being knocked out for. I was semi conscious the entire time, but I couldn’t feel or hear anything. I just knew people were all around me doing something. It feels like I was dead for a while. I have very few memories from the time they first gave it to me in the ambulance to the time I woke up at home the next day.

      Fucking awful experience all around. Next time I was in the hospital for an unrelated condition I told them I’d rather have zero pain medicine than even a tiny amount of ketamine

        • @kboy101222@lemm.ee
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          37 months ago

          They gave me low dose in the ambulance. While it was a decent high, I still had the same memory issues (which I always have while high, but at least I can normally remember something)

            • @kboy101222@lemm.ee
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              7 months ago

              Good to know, especially since the ambulance really didn’t give me much.

              I’m still gonna pass on it though cause that was such an awful experience and I’d much rather just take an edible

      • wia
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        6 months ago

        I don’t understand why this is bad?

        I’m reading this like you’re unhappy you don’t remember the pain? And you want pain?

        Or is this sarcasm?

        • @kboy101222@lemm.ee
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          16 months ago

          No, it’s basically an entire day of my life that I know happened but I can’t remember any specific details of. I know I went through insane amounts of physical and emotional trauma (I laid there in pain for no less than 8 hours because it was literally the same week COVID started), and not being able to remember it at all is preventing me from moving on or healing.

          Idk if it’s just a me thing, but I hate not remembering entire large sections of time. After the first time I got black out drunk I didn’t drink alcohol for almost 2 years

        • @kboy101222@lemm.ee
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          27 months ago

          Absolutely no idea. The other hospital I mentioned was confused as to why they did it as well.

    • @chitak166@lemmy.world
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      -87 months ago

      Doesn’t surprise me at all!

      The groups of ‘friends’ that do shit like ketamine are almost always scumbags just keeping each other down.

      • Bleeping Lobster
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        77 months ago

        I think you and I had very different experiences! While ket abuse can defo lead to paranoia and becoming more insular, in my circles it was taken at hard house / trance events or after parties. Lots of silliness and fun times.

        Unfortunately for my friend, he lived on his own in Manchester and fell in with a rough crowd after moving to Salford :'(

  • @HonoraryMancunian@lemmy.world
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    7 months ago

    Matt Le Blanc:

    "…I guess you’re keeping the 20 bucks you owe me.”

    This is exactly the kind of humour Perry would’ve appreciated

    • NoSpiritAnimal
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      867 months ago

      He is not just truckin’ along. The man looks like someone’s aunt is trying to build mass. He looks like an uncooked weisswurst got a planet fitness membership. He is a torso made manifest. Hair plugs and ozempic riding the right-wing-pipeline down a k-hole.

    • sharpiemarker
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      7 months ago

      Hot tubs + drugs don’t mix. Even alcohol is dangerous because the effect of the hot tub increases the effects. We bought a hot tub recently and they’re are dozens of warnings about drugs/alcohol.

      My recommendation to Elon would be to have a nice big dose and take a long dip.

  • @spiderkle@lemmy.ca
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    7 months ago

    Takes note: Don’t do horse-tranquilizers alone in a bath, check. As a matter of fact don’t do any analgesic/anesthetic with additional drugs in a bath, also check.

    • @RocketBoots@programming.dev
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      7 months ago

      Calling them horse tranquilizers is misleading. Ketamine was and still is used in medicine and is on the WHO list of essential medicines.

      My cat is prescribed gabapentin. Some even get tramadol. Warfarin literally was rat poison until we got all but the craziest SOBs with an abundance of vitamin K in they’re veins.

      • @Dozzi92@lemmy.world
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        147 months ago

        Yeah, I feel like there is a war on K because it can absolutely replace opiates in pre-hospital pain management. Break a leg? Let the medics hit you with ketamine. Oh, your BP is a little low? No worries, ketamine doesn’t care.

        It is better than an opiate with none of the contraindications. And I’m oversimplifying, but I can’t help but think some of this news coming out is almost a hit piece to dub ketamine dangerous, when it is, in fact, magnitudes safer than opiates.

      • @Hadriscus@lemm.ee
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        6 months ago

        oh, I tried that last month ! Pretty sweet high, relaxing. Like a really soft mdma (really soft!)

        (I was talking about gabapentin, just realized it was ambiguous)

        • @EatATaco@lemm.ee
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          367 months ago

          If I say I’m serving cat food for dinner, and then whip out a nice piece of salmon sashimi, I wasn’t being misleading because cats eat fish? If so, you’re really killing some of my dad jokes here.

        • prole
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          7 months ago

          It’s also used on infants for anesthesia due to how safe it is.

          Maybe we should start calling it “baby tranquilizer” instead?

  • Rob T Firefly
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    7 months ago

    When Friends was current I wasn’t a fan, the small bits I’d seen mostly annoyed me and - disaffected gothy teens/early twenties guy that I was - I dismissed it as one of those things everyone in the mainstream liked and was therefore obviously garbage.

    Nowadays I’m married to a Friends fan who has begun showing me the series. As we progress through the box set I’m realizing it’s actually pretty good, a couple of the characters actually still annoy me when they’re focused on but there’s a ton else going on that’s pretty entertaining. I’m particularly surprised to be enjoying Chandler so much.

    It’s very sad what Matthew Perry went through in life and how he died, but I’m now belatedly appreciating some of the work he did.

      • @kameecoding@lemmy.world
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        166 months ago

        you can’t just do that mate, same with Seinfeld, they were filmed in front of a live audience, they had to stop for laughter otherwise you wouldn’t hear what they are saying.

        or are you gonna come out and say Seinfeld isn’t hilarious?

    • @Underwaterbob@lemm.ee
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      147 months ago

      I’m still not sure I’d call it good, but it was a big step up from sitcoms before it. It tried pretty hard to not be sexist, and introduced some diversity that wasn’t just John Ritter pretending to be gay for lulz. It is still spectacularly unrealistic, but whatever. It’s a sitcom! It does have some genuinely funny moments.

      I still periodically get “Smelly Cat” stuck in my head. Fuck, I’m guilty of making Ross-esque synthesizer music…

      • Rob T Firefly
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        7 months ago

        Very true. There are also definitely still some 1990s-era LGBTQIA+ phobic jokes which were wrong then and really stick out now, but in general I’d call the writing surprisingly decent.

        As a New Yorker, though, I still couldn’t afford that apartment in a million years.

        • @Tavarin@lemmy.ca
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          157 months ago

          I still couldn’t afford that apartment in a million years.

          Neither could they, it was rent controlled due to Monica’s grandmother living there, and they illegally kept her name on the lease for the cheap rent.

          And Chandler made good money, so he could afford the smaller 2 bedroom.

  • @saze@feddit.uk
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    217 months ago

    Damn, I did not know Ket could depress respiration like this! In fact Ket is used medicinally in place of opioids as it doesn’t depress respiration. But here is the TIL part: it should not be mixed with benzos or alcohol (or other depressants I would imagine). I don’t use bu I hope someone who does get to read this.

    • @14th_cylon@lemm.ee
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      7 months ago

      ketamine is anaesthetic and was used in the past in combat medicine and such, because it is quite safe when administered by untrained staff. the fact it is used to treat depression is new to me, but getting in the pool while high on it is the most stupid idea ever :(.

    • @Staiden@lemmy.dbzer0.com
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      167 months ago

      As someone who enjoys the near death experience of being a flattened disk of light energy folding in space time, this makes me sad.

      • @intensely_human@lemm.ee
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        77 months ago

        Don’t worry. Consciousness is immortal so you’ll be able to live as much time as you want as a disc of light or whatever.

        • @Staiden@lemmy.dbzer0.com
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          67 months ago

          So I wouldn’t actually want to be stuck in it forever. It’s hard to explain but my k-holes are quite dark and dreadful, it’s what I explained in my previous comment except looping. I don’t have a physical body anymore and I’m just a thought process floating through space in a stream of color. There’s this creeking noise like a door opening that starts off real low pitch and slowly speeds up to the point it’s high pich and extremely fast. Then it’s like hitting a wall and you fly in to a million pieces an slowly gather yourself in that state and then it repeats.

          It feels like that is what you have been since the beginning of time. It feels like a near death experience and when i come out some kind of reverse psychology goes on in my brain. I just think about how much it would suck if that was real. My depression goes away for quite awhile afterwards.

          • @intensely_human@lemm.ee
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            17 months ago

            Whenever I do nitrous, I see this same truth. The truth is that the universe has four phases. Being high on nitrous and seeing the structure is one of the four states.

            There’s some kind of four-phase clockwork thing chugging along. Normal existence I think is one of the states?

            I can’t remember. All I can remember is being astounded, every time, that I’m back in the “aware of what’s going on phase”, and I struggle mightily to remember the lesson, knowing I won’t be able to because the next phase is defined by my ignorance of it.

            It’s maddening.

            I’d love to do some serious ketamine sometime. I did a little line at a party once in 2006 and that was for my ketamine experience. It was a tiny bump and didn’t really affect me much. Nothing even remotely psychedelic, that I recall.

            At that same party I did a huge hit of fucking homemade habanero extract (on purpose) and that was way more mind-blowing.

          • @intensely_human@lemm.ee
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            -57 months ago

            Unfortunately it doesn’t matter if you want to or not. You are literally never going to die.

            You can die in other people’s worlds, but not in your own. Other people will die in your universe, but your own life will, beyond all odds, only continue forever.

            You’ll die in others’ universes of course. Other people will lose you. But you’ll never lose yourself.

            No choice, pal.

            But I don’t think you’ll be human the whole time. Human lifespan is a century or so. So the story of your life will have to change to account for your survival. Eventually, no human story will suffice any longer. In these other timelines where you survive, you may be uploaded into a machine, or possibly disconnect from your body via astral projection, or wake up in a simulated universe instead, with different laws around death.

            But at some point during the eternity, you’ll probably be the disc of light. I’m guessing trillions of years out, after the heat death of the universe has rendered it incapable of supporting any kind of life as we know it.

            This is something I recently learned, actually. That we’re immortal.

        • Flying Squid
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          27 months ago

          My awareness going on forever sounds hellish. I don’t want to only live 70-100 years, but I also wouldn’t want to live 1000 years, let alone billions.

          So I sure hope you’re wrong on that front (and I think you are). The universe is a cruel enough place as it is.

      • @lingh0e@lemmy.world
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        27 months ago

        My man.

        I’ve been there too. I saw the singularity and touched god… and I’m a goddamn atheist. Coming back from that experience changed me. The memories were fleeting. I couldn’t remember the specifics after I returned to baseline. All the knowledge that I was given dissipated… but the overwhelming sense of calm persisted.

        If I’m gonna die, it’d be a good way to go out.

        • @Rai@lemmy.dbzer0.com
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          16 months ago

          My biggest k-hole was my most terrifying and incredible experience I’ve ever had. I haven’t done it since. I will again someday.

          The curtain of consciousness was peeled back and I saw what was beyond life and time and brain. It was neat, it horrified me.

  • @IDontHavePantsOn@lemm.ee
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    107 months ago

    Im fairly certain that what I’m about to say will be disliked by ketamine users and abstainers.

    Ketamine is garbage at everything besides temporarily lobotomizing people. It works for it’s many uses because it makes the user stupid. It’s often given to suicidal people, not because it’s a miracle drug, but because it incapacitates them in a safe manner.

    That said, it’s great at making people too stupid to be able to hurt themselves, most of the time. It’s great at numbing psychological pain because the user will be too stupid to conceptualize their own thoughts or realize where they are physically.

    It’s also hard on the urinary system and has a fleeting high.

    If you like ketamine then by all means, you do you. If you may be interested in trying ketamine, become a zombie safely, just don’t expect it to cure your depression, woes, or any of your other problems.

    • @StorminNorman@lemmy.world
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      487 months ago

      Yeah, I’m gonna take the peer reviewed studies results that show that ketamine is quite effective with relieving drug resistant depression over this post of yours…

      • @figaro@lemdro.id
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        57 months ago

        It is useful in creating a sense of disassociation of self - the same thing that meditation does. It even affects the same regions of the brain as meditation. When used carefully, with therapeutic intent, it can be an effective treatment for depression.

        Recreational use is sketchy, definitely. But the science is there for using it therapeutically.

      • @madcaesar@lemmy.world
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        -57 months ago

        I have no dog in this fight, but any studies done on brain chemistry and psychological effects need to be taken with a grain of salt. We know so little about the brain and consciousness that most of the stuff we’re trying and doing are educated guesses.

        • @StorminNorman@lemmy.world
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          147 months ago

          Ketamine is garbage at everything besides temporarily lobotomizing people. It works for it’s many uses because it makes the user stupid. It’s often given to suicidal people, not because it’s a miracle drug, but because it incapacitates them in a safe manner.

          This quote from you contradicts what you’ve just said.

          • @IDontHavePantsOn@lemm.ee
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            -87 months ago

            It doesn’t. I can speak to it’s mode of action without speaking to it’s reason of use or efficacy. It’s highly effective. It’s great at what it’s used for. It also temporarily makes the user stupid and incapacitates them.

            • @Metacortechs@lemmy.world
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              207 months ago

              That isn’t it’s mode of action, at all.

              It also doesn’t make you stupid, it is a disassociative anesthetic so you lose touch, to varying degrees, of your senses. At high enough doses even your sense of hearing becomes strange and I would bet if my doc gave me more it would fail almost completely. That’s not a place I want to go however.

              Despite that, and appearing to be incapable of coordinated movement or speech, the mind is still active. Altered, yes. But active and intact. I am always aware of my partner in the room/bed with me, the dog checking things out, I just choose not to interact with them to continue exploring memories, or alien landscapes, or just turn off my mind, listen to the music, and let the drug work while the most fantastic and surreal images come and go.

              I’m here today because of ketamine. Disinformation and pearl clutching threatens to reduce access to it, and could cost lives, speaking only of this one niche use.

              • @IDontHavePantsOn@lemm.ee
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                -17 months ago

                I’ve ingested a ton of ketamine myself, so theres no pearl clutching here. I’ll be back tomorrow to continue arguing semantics.

              • @IDontHavePantsOn@lemm.ee
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                -16 months ago

                I’m not trying to diminish anyone’s experiences with ketamine, or reduce anyone’s access to it, though I do think it’s funny everyone thinks that some asshole on the internet has that ability.

                Are you able to stand up when using ketamine? How about run? Could you tell me your personal details such as name/date/address? Could you tell me the time? Could you remember your mother’s phone number? Could you take a bath? Could you safely use a knife? Could you melt into nothingness and lose all sense of self, physicality and emotion?..wait strike that last one. Of course you could.

                Now we’re at the point that we all realize dissociation is to become stupid and incapacitated. Anesthitized even?

                • @StorminNorman@lemmy.world
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                  06 months ago

                  Ahhhhh, so you did come back to say more dumb stuff. I literally baby sat a group of friends on the stuff two weekends ago. Sure, they said some amusing things, but at least 95% of what they said was perfectly coherent and made sense. As evidenced by one of them saying “you know you’re getting old when you have more cos you’re lower back starts to ache”. By your description, that should not have been possible. Yet it was. Sure, you enter a k-hole and you’re good for nothing, but most K experiences don’t enter that and people can function fine enough on it - like most drugs the intensity of effect is dose dependent. But like I said in a previous comment, you seem to be stuck in the 1950s and their anti drugs hysteria.

            • @StorminNorman@lemmy.world
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              47 months ago

              You didn’t though. You used a blanket statement. As evidenced by your use of the word “everything”. Your entire initial comment reads as if it was written in the grip of anti drugs hysteria in the 1950s and shows none of the nuance you’re now trying to claim it does.

              You’re also wrong on its mode of action, so you’re not even speaking to that. It doesn’t work by making the user “too stupid to conceptualize their own thoughts or realize where they are physically”.

    • @butterflyattack@lemmy.world
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      7 months ago

      I would add to this that anyone doing ketamine should not do it in the bath, which seems to be what happened here. The same happened to someone I knew, she drowned in the tub.

    • @chitak166@lemmy.world
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      -217 months ago

      Ketamine is definitely up there with ‘hip’ drugs not worth trying.

      Along with MDMA and Xanax.

      I don’t really respect anyone who does these because they’re usually living a lifestyle that leads to nowhere.

      • @smooth_tea@lemmy.world
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        67 months ago

        MDMA not worth it? It’s euphoria and love in a pill, not addictive, and quite safe when you do not abuse it. Millions of people use it and have been using it for about half a century and the vast majority of it restricts it to when they’re partying with few side effects. I think you misjudge its use a bit.

        Yes it can be acutely abused because you’re chasing the dragon on nights that you do use it, but that is also a result of its illegal nature and a lack of education.

        Of the chemical variants of drugs, I’d say it’s probably one of the few that is actually worth it, besides LSD.

        • @Dozzi92@lemmy.world
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          17 months ago

          Yeah, I try to tell people that there’s value in MDMA beyond just a night out dancing. My favorite times have been on a couch with friends, getting deep into one another and kind of exploring your minds. I’ve had some incredibly important and memorable conversations with people that I was able to become very close with because MDMA let us drop the walls and talk about things, which is something I cannot do face to face with someone sober. And I’m not an introvert by any stretch, I have no problem being the center of a conversation, I have no problem listening to others, but opening up about personal issues was something MDMA let me do, and say things I never could put into words.

          I’ve also stood in front of a wall of speakers and had bright lights and bass music thrown at me, and that’s also fun.

      • @Hadriscus@lemm.ee
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        47 months ago

        Hmmm, I don’t know the second one but mdma is great fun. Of course you have to be in a good state of mind before trying, but it’s a potent empathogen that has its uses.

        • @EatATaco@lemm.ee
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          47 months ago

          One of the most fun nights of my life is when I went to visit a friend at his university, we took some and he immediately ended up with some girl and disappeared on me.

          So I decided that I would just wander his campus looking for parties. I took shots with frat boys, danced with some gays guy out dressed in drag, played chess with some guy on the quad (he would have destroyed me even if I was sober), found another friend and went and partied with her and her lesbian friends (“wait you’re a lesbian now?” “Maybe not sure”) and then made the biggest mistake of my life when I turned down joining them when I was making a hasty exit after I noticed one of the girls was eating the other out right next to me on the couch.

          • @Hadriscus@lemm.ee
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            7 months ago

            wild 😁 Yea I get how you’d want a do over heheh

            My experience is very vanilla coming after yours, but we had some of that and spent the entire night in my last floor apartment just chatting and drinking looking at the sea. It was full moon too. At one point I must have thought it was around midnight, I peeked at the east-facing window in my room and a big ball of fire was burning on the horizon. Time really flew this night…

  • @vankappa@lemmy.world
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    77 months ago

    I didn’t even think it was possible to die from ket. Although doing lots of ket in the water sounds like a planned suicide

      • @LemmynySnicket@lemmy.world
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        47 months ago

        I was looking up psilocybin and was surprised to see the mean fatal dose for a bunch of lab animals. Didn’t bother equating it to humans, but I was surprised.

        • @xantoxis@lemmy.world
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          37 months ago

          Erm, it’s really truly not that dangerous.

          Let’s start with this chart (colorful chart near the top). The yellow-green bar on the right is cubensis, the most common shroom. 0.6% by weight. A typical dose of shrooms is gonna run about 0.5g to 2g, meaning a typical shrooms trip hits you with up to 12mg psilocybin. A shroom is roughly half a gram, maybe a whole gram, let’s just use 1g shrooms for simplicity–6mg of drug mass in that shroom.

          LD50 for psilocybin is 280mg/kg. This is how LD50 is always measured–amount of drug (in mass units) per kg of body weight, in order to reach a 50% likelihood of fatal symptoms resulting in death.

          Now, the average adult weight is somewhere in the 50-100kg range. Let’s take someone on the lighter end at 50kg. How many shrooms would our dainty psychonaut have to take to have a chance of dying? The math is simple: 280 * 50 / 6 gives us (LD50 * shroom count) for a grand total of: 233 largish shrooms, taken rapidly, to have a chance of dying from it. Now, you could refine it and pack that much of the drug into a much smaller dose than 233 shrooms, but we’re getting into silliness at this point.

          Basically, don’t take hundreds of shrooms at once and you’ll be aight.

          • Doubletwist
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            16 months ago

            The math is simple: 280 * 50 / 6 gives us (LD50 * shroom count) for a grand total of: 233 largish shrooms, taken rapidly, to have a chance of dying from it

            You mean to get to the point where you have a 50% chance if dying from it. You still have a chance (<50%) of doing from it at much lower doses.

      • @14th_cylon@lemm.ee
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        7 months ago

        it is actually really hard for ketamine to kill you, that is why it was used as anaesthetic in combat medicine, because it is safe to be administered by untrained staff. but it is really important not to anaesthetize yourself in the pool :(.

    • Dale
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      67 months ago

      I’ve never done ketamine but going into a K-hole in a hot tub sounds incredibly dangerous. I don’t know what’s more sad if it was planned or not.

    • @RedAggroBest@lemmy.world
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      37 months ago

      If another comment was to be believed, he had heart disease. Ketamine plus a hot tub, probably alcohol (? Someone correct me if I’m wrong please) my chest hurts just from thinking about that. His heart probably damn near ruptured

    • @orbitz@lemmy.ca
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      -27 months ago

      Anything that has the effect of Ketamine would easily kill in the right amount, let alone in a pool of water. If they use it as animal anesthesia its probably pretty potent. Can be fun in the right amounts but got to be safe and careful.

    • @kernelle@0d.gs
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      86 months ago

      Perry had been undergoing ketamine infusion therapy prior to his death, reportedly for depression and anxiety. The toxicology report adds: “At the high levels of ketamine found in his postmortem blood specimens, the main lethal effects would be from both cardiovascular overstimulation and respiratory depression.”

      He was getting it as treatment, but technically yes

      • @Thetimefarm@lemm.ee
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        fedilink
        26 months ago

        He was definately taking it recreationally too, a therapeudic dose wouldn’t even be close to enough to OD on. Long term ketamine use can have it’s own risks if the dose isn’t kept very low.