Idk about other chemicals, but THC can be absorbed through the stomach lining and mouth, there it would bypass “processing”.
But it also doesn’t need to process all the food first, it would dissipate and essentially be evenly distributed through the food as it gets absorbed and processed.
Like all chemicals you ingest - for max effect take them on an empty stomach and then eat at least a moderately sized meal afterwards.
If you take them on a full stomach then your body needs to process all the food first, and your body will process the edible slowly.
If you take them on an empty stomach and never eat, your body might not metabolize it quickly either.
Idk about other chemicals, but THC can be absorbed through the stomach lining and mouth, there it would bypass “processing”.
But it also doesn’t need to process all the food first, it would dissipate and essentially be evenly distributed through the food as it gets absorbed and processed.