I already disliked all the references to US history in Fallout 4. To me, cowboys feel misplaced in a science fiction universe. It’s just personal preference though. But the question stands: are large parts of the main story related to the cowboy characters, or does it work mostly without?
Yeah, I think so. I’ve got 40 hours in and only spent pretty much the bare minimum time in Akila which I’m pretty sure is the home base for the cowboys. While there are quests to be done and XP to be gained, I will probably leave Akila for when I start to get tired of other gameplay and want something different.