In trials
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When this was posted before someone who followed it fairly closely and others like it, updated the thread with info because the article was behind current info. They had already stopped the trials for MS because it wasn’t working. So they began to just focus on one other, the Crohn’s, I believe. Figuring if they got one to work, they could go back to the others and get them on the right track.
I have MS, and while this is a new approach, there have been so many articles about treatments that end up going nowhere after the first excitement. So it is still very early to get hopes up.
Hope can be a dangerous thing. Hope can drive a man insane, as Red said.
Is it possible that other person was just full of shit?
Here was an update posted on Sept 12th, 2023 from the company behind the trials regarding the MS trials:
Anokion has completed patient enrollment early in the second and final MAD cohort of its MoveS-it (Multiple Sclerosis Study of ANK-700 to Assess Safety and Immune Tolerance) clinical trial to evaluate ANK-700 for the treatment of patients with multiple sclerosis. MoveS-it is a randomized, double-blind, placebo-controlled Phase 1 study evaluating ANK-700 for the treatment of patients with relapsing remitting multiple sclerosis (RRMS). MS is a demyelinating disease of the CNS, in which the immune system attacks the myelin sheath in the brain and spinal cord. RRMS is the most common type of MS, characterized by recurring episodes of new or worsening symptoms. Anokion has designed ANK-700 to re-educate the immune system by inducing antigen-specific tolerance to myelin-based autoantigens to reduce neuroinflammation in the brain and spinal cord.
Safety data from both the SAD and MAD cohorts supports that ANK-700 is safe and well-tolerated at all dose levels tested through the dose escalation period. Further, preliminary biomarker data from the MAD cohorts displays trends in antigen-specific immune tolerance and evidence of bystander suppression to related myelin antigens, which is critical to treating complex autoimmune diseases like MS.
The study will continue with a 12-month safety follow-up expected to complete in the first half of 2024. Anokion anticipates reporting full results from its MoveS-it clinical trial in the second half of 2024.
This says that the single dose (SAD) phase 1 trial which began in 2020 was completed and they moved on to the second multiple ascending dose trial (MAD) for MS which completed enrollment and expect results in 2024. And that the preliminary data from the first MAD trial indicates therapeutic response.
And the press release talks about how they’ve moved on to a phase 2 trial for its use for celiacs (the initial trial use case). And then on Oct 12th they announced they will be presenting data from their phase 1 for celiacs at a conference.
A week after the announcement quoted above they released the news about their peer reviewed paper mentioning the early success in both (what likely inspired OP’s article), saying:
We have now observed our approach play out in the clinic with early data from our lead programs in celiac disease and multiple sclerosis, KAN-101 and ANK-700, that demonstrated antigen-specific tolerance, bystander suppression, and an impact on disease-specific biomarkers.
None of this looks like a company that has a failing drug on their hands. And there’s no indication of the MS trial being ended early - the only thing that happened early was completing enrollment early.
Being too ready to give up on hope is its own kind of insanity.
T1 diabetes here. A cure is just 5 years away…
They told me, when I was diagnosed in 1992.
It always 5 years if properly funded. It’s never properly funded so always 5 years.
They are testing an artificial pancreas currently. The cost is the issue as always.
We can genetically engineer bacteria to mimic the missing pancreatic cells, and it’s not too different to the way most insulin is produced as all that’s new is the system to stop producing insulin when blood sugars are already low enough. However, if you put them in a person, the immune system attacks the bacteria, so they need isolating. To do that, we need a membrane that lets sugar in and insulin out, but doesn’t let antigens or live bacteria out, and doesn’t let immune cells in. Even if the bacteria are held in place, if immune cells can get in, it’s no better than a pancreatic transplant as you’ll still need immunosuppressants, and they’re generally worse than dealing with type one manually. Development of the membrane keeps hitting unexpected hurdles, so artifical pancreases are still unable to start trials, and then they might take a decade.
There are other approaches, e.g. using electronics to control photosensitive insulin producing bacteria, but they don’t have any advantages (the membrane still has to let sugar in so the bacteria can eat) and have more things that can go wrong.
Well damn, I got MS too but caught it fairly early. I’m hoping for a major breakthrough before it gets really bad.
So, if I understand this right, a more accurate title would be “Research into vaccines against autoimmune diseases continues, new data indicate that a change of focus might be needed”
I came for the Orange reference, but was not disappointed by Red.
have Crohn’s. fingers crossed 🤞🏽
Website I’ve never heard of: check
Wild claims that seem too good to be true: check
Little to no proof about said claims: check
Don’t get me wrong, this would be fantastic if it’s true. But I’m sceptical. It feels like all those articles about a cure for cancer that then never go anywhere.
Here’s the article that should have been posted, except of course that it’s a few months old and nothing new has been reported on it yet that I know of. https://pme.uchicago.edu/news/inverse-vaccine-shows-potential-treat-multiple-sclerosis-and-other-autoimmune-diseases
I see it in google news all the time. spammy but I don’t see their ads. they gave references near the end.
Every science article is just a comment section disapproving the article. That’s why I stay away from these science communities, it’s all clickbait and lies
At the same time, commenters don’t necessarily know what the fuck they’re talking about either.
Looks at that… The one thing good about reddit was the /r/science sub, it was always full of moderator deleted comments that were off topic, factually incorrect, etc. posted articles actually were scientific reports and not clickbait crap lik this
Wait. I read above that this article is good. No?
deleted by creator
okay then
This sounds quite exciting and it doesn’t smell like bullshit.
Probably extremely affordable at 3 million a pop for 5 shots.
Easy hack. Get a bunch of more affordable health care services during the year until you reach your out-of-pocket max, then go in and get your 3 million worth of shots all on the insurance company’s dime with zero extra cost to you.
Your claim was denied, due to the insurance provider classifying this treatment as elective or cosmetic, not life saving.
Ah, I see you’ve interacted with the American “health insurance” extortion racket.
Frequently, yes.
Article from September. First I’m hearing of it…
If we assume for a moment that it works as advertised - what is it that makes this a vaccine? To me it sounds like a cure or treatment.
The creators call it an inverse vaccine. A vaccine causes the immune system to recognize a compound to attack. This treatment causes the immune system to ignore a compound it had previously recognized. So they are specifically saying it’s not a vaccine (and OP is misrepresenting them), even though that word is in the phrase, something roughly like antivenom is not a venom.
Thanks for the additional clarification!
@be_excellent_to_each_other @m3t00
Vaccines have evolved from prevention/mitigation to now include treatment, and ideally cures.So skimming through the link, it’s a vaccine because it’s still triggering a specific body response to fight the illness as opposed to directly attacking the illness itself? Is that a reasonable layman’s summary of why it’s called a vaccine?
(Old x’er here, Vaccines have been preventative for as long as I’ve ever known, that’s the reason for the question.)
@be_excellent_to_each_other @m3t00
I an X that had the exact same thoughts lol. I’m no expert, but old vaccines often contained some of the virus live or deactivated, whereas mRNA are created and not of biological origin. So more about the front end than the back end.
The amount of science research funded over COVID that allowed for the rapid development and testing of mRNA technology has created a boon for centuries to come. COVID may well be responsible for the death of autoimmune diseases.
Oh fuck yes! I hope this works so badly (living the nightmare with crohns)
I wonder if it also applies to ulcerative colitis…
One of us…
Hi there! Looks like you linked to a Lemmy community using a URL instead of its name, which doesn’t work well for people on different instances. Try fixing it like this: !crohnsandcolitis@lemmy.world
Thanks, subscribed :)
Same here friend. The disease is rough and hits everyone differently. Hope you’re doing alright with things tho :)
I would give anything to be rid of this disease. I haven’t slept a full night since 1996. And the pain… And it always seems like nobody understands. ‘Oh him? He just poops a lot, ignore the doom and gloom.’
@Bo7a @CleoTheWizard
Me too 🎯
Only “ten more years to cure diabetes”
-Science 30 years ago
This still wont cure diabetes, but it will prevent it from developing or advancing if you catch it early enough.
Curing diabetes isn’t as profitable as selling insulin. That’s why it doesn’t get funded.
This doesn’t hold any water, logically.
If you’re selling insulin and I cure/prevent diabetes with a single treatment t, you no longer have a market and I have literally every human being on the planet.
Medical science is an arms race, and cures are nukes. You make the best cure, you win. Full stop.
Medical science is an arms race, and cures are nukes. You make the best cure, you win. Full stop.
You would think that, except pharmaceutical research is rigged towards the few giant corporations that hold the patents. Sure, medical research is an arms race, but who is funding your research? If you find a cure but Pfizer funds you they can patent the cure and bury it or make it cost prohibitive in a variety of different ways.
The original insulin patent is open. Then why does it cost so much money to get insulin for Americans? Again, corporate patent trolling and controlling the funding for research labs. This is why corporate monopolies need to be regulated.
(Also I didn’t realize we do downvoting for disagreements on Lemmy now too)
I didn’t downvotes you for a disagreement, but because you’re spreading false conspiracy theories in a science community.
Also I get downvotes for saying true things people don’t like all the time. It isn’t a big deal.
Sure, I’m spreading conspiracy theories. Not like I left chronic disease research and restarted in a completely unrelated field for this exact problem.
I didn’t work for Pfizer, but I did work for another pharmaceutical company you would recognize the name of if you live in North America. And let me tell you, while the labs are trying to do good, the executives and management are rotten to the core. Unless it’s a life threatening infectious disease, they will not prioritize the research. It’s not active suppression most of the time, it’s willful negligence and underfunding. I got into the field hopeful, and left jaded.
It’s not active suppression most of the time,
This is your initial claim, though.
No, my initial claim was:
Curing diabetes isn’t as profitable as selling insulin. That’s why it doesn’t get funded.
Then you opined that whoever comes up with a cure wins, which should be true in a perfect world. In fact, most researchers would agree with you.
Unfortunately, a lot of MBA’s in these pharma companies don’t see it that way, and my reply to you was trying to outline the realities of that. I focussed more on the patent-and-bury part because this is the one method less known to the public (and less used), but underfunding research that can do a public good but isn’t profitable is a common technique by corporations in research, regardless of the discipline.
My bad, I thought this was common knowledge, but it probably isn’t for people who aren’t in PhD/post-doc research roles.
This is the most boomer shit and it is so sad to see people still saying it
In my understanding this could reverse the autoimmune reaction to Type 1 Diabetes not regrow the already killed β-cells.
I was wondering about that, curing Type 1 Diabetes would be a HELL of a breakthrough.
Curing it would lead to massive losses of a specific industry.
It really would. I fear that anything remotely close to a “cure” would be thwarted by pharma because they profit so much from insulin.
I switched jobs a few months ago, and had about 2 weeks without insurance. my insulin prescription was over $4k.
I know that “pharma” can’t just shut something down… but I’m sure there’s some loophole
Call me when the human trials give a positive return
Patience Padawan.
I have 1 autistic kid with T1D and 1 kid with celiac. I’m confident in next 10 years both will be cured.
I’m guessing you mean the diabetes and celiac will be cured, not the autism
Lol yes. I am not a crackpot
I wonder if a similar technique could be used to reduce organ transplant rejection.
Same but allergies.
Awesome, I have an autoimmune desease that can possibly paralyse me in future. I hope progress can continue 🙏
That’s a bold claim there, dennis
Not only that, it is a repost from three months ago. Not that OP would be expected to know, but it does take off a few “groundbreaking” points.
I mean, it’s making it to human trials so seems a lot more real than most of these “kills cancer cells in a petri dish” sort of things.
What I mean is the actual article linked to is already months old. Also, that’s great, but it’s not out of the woods yet.
What about Hashimoto’s thyroiditis and Graves’ disease?
I remember seeing something on reddit about this earlier this year iirc. Definitely exciting and I certainly hope there is credence to this. Would love to see auto immune disorders go by the wayside in the next couple decades. Once they fix all the real bad ones I hope they make one for vitiligo, I’m tired of 70 spf sunblock and weird looking tans.
Sounds pretty advanced. I bet they won’t be able to activate the mind control chips until 6G cell services launch.
