A new discovery reveals that astrocytes, star-shaped cells in the brain, play a key role in regulating fat metabolism and obesity. These cells act on a cluster of neurons, known as the GABRA5 cluster, effectively acting as a “switch” for weight regulation.

The MAO-B enzyme in these astrocytes was identified as a target for obesity treatment, influencing GABA secretion and thus weight regulation.

KDS2010, a selective and reversible MAO-B inhibitor, successfully led to weight loss in obese mice without impacting their food intake, even while consuming a high-fat diet, and is now in Phase 1 clinical trials.

  • @jhulten
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    1910 months ago

    It’s also easy easier to discriminate against far people if you can define it as a moral failure of just not putting food in your gob.

    • Scribbd
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      fedilink
      510 months ago

      Unlike close people. Those are always bastards invading personal spaces.